Nature Medicine Contents: Volume 30 Number 4

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In this Issue: Editorial News News Feature Correspondence World View Comment News & Views Research Briefings Perspectives Review Articles Brief Communications Articles Analysis Amendments & Corrections

Nature Medicine Contents: Volume 30 Issue 4

Editorial

Microplastics are everywhere — we need to understand how they affect human health Editorial | 19 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02968-x

News

How AI-powered handheld devices are boosting disease diagnostics - from cancer to dermatology Paul Webster News | 12 March 2024 Nature Medicine 30 | doi:10.1038/d41591-024-00016-2

News Feature

Food is medicine: clinical trials show the health benefits of dietary interventions Priya Venkatesan News Feature | 08 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02891-1

Correspondence

The European Network for IgE-Mediated Autoimmunity and Autoallergy (ENIGMA) initiative Pavel Kolkhir, Sabine Altrichter, Fariza Mishaal Saiema Badloe, Hafsa Belasri, Nicolas Charles et al. Correspondence | 01 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02819-9

To understand mRNA vaccine hesitancy, stop calling the public anti-science Patrick Peretti-Watel, Pierre Verger & Jeremy K. Ward Correspondence | 27 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02816-y

Using explainable artificial intelligence to predict and forestall flare in rheumatoid arthritis Stefano Alivernini, Juan D. Cañete, Jaume Bacardit & Mariola Kurowska-Stolarska Correspondence | 15 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02818-w

Information is a determinant of health Garth Graham, Nira Goren, Viknesh Sounderajah & Karen DeSalvo Correspondence | 13 February 2024 Nature Medicine 30 | doi:10.1038/s41591-023-02792-9

World View

Why diversity is needed at every level of clinical trials, from participants to leaders Khadijah Breathett World View | 11 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02914-x

Comment

Implementation of community screening strategies for depression Jorge Arias de la Torre, Amy Ronaldson, Gemma Vilagut, Gonzalo Martínez-Alés, Alex Dregan et al. Comment | 27 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02821-1

Steatotic liver disease: a new name to reflect the combined role of alcohol and metabolic dysfunction Aleksander Krag & Mary E. Rinella Comment | 08 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02849-3

Promoting gender equity in the scientific and health workforce is essential to improve women's health Cristiani Vieira Machado, Cristina Araripe Ferreira & Maria Auxiliadora de Souza Mendes Gomes Comment | 22 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02872-4

News & Views

Functional precision medicine for pediatric cancers M. Emmy M. Dolman & Paul G. Ekert News & Views | 11 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02863-5

Large language models for reducing clinicians' documentation burden Kirk Roberts News & Views | 01 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02888-w

Using unlabeled data to enhance fairness of medical AI Rajiv Movva, Pang Wei Koh & Emma Pierson News & Views | 19 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02892-0

Telehealth enables safe medication abortion in shifting health and legal contexts Dana M. Johnson, Abigail R. A. Aiken & Terri-Ann Thompson News & Views | 15 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02876-0

Research Briefings

Deciphering the genetic architecture of pain intensity Research Briefing | 14 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02881-3

Systematic testing in cholera surveillance enhances vaccine impact and cost-effectiveness Research Briefing | 03 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02907-w

Testing pooled samples enables universal screening of congenital cytomegalovirus infection Research Briefing | 21 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02901-2

Extreme weather events have lasting impacts on risk of death and healthcare utilization Research Briefing | 29 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02868-0

Revealing clinical heterogeneity in a large brain bank cohort Research Briefing | 20 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02871-5

Perspectives

Causal machine learning for predicting treatment outcomes Stefan Feuerriegel, Dennis Frauen, Valentyn Melnychuk, Jonas Schweisthal, Konstantin Hess et al. Perspective | 19 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02902-1

Review Articles

Targeting KRAS in cancer Anupriya Singhal, Bob T. Li & Eileen M. O'Reilly Review Article | 18 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02903-0

Brief Communications

T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy Guido Ghilardi, Joseph A. Fraietta, James N. Gerson, Vivianna M. Van Deerlin, Jennifer J. D. Morrissette et al. Brief Communication | 24 January 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02826-w

Articles

Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers Arlet M. Acanda De La Rocha, Noah E. Berlow, Maggie Fader, Ebony R. Coats, Cima Saghira et al. Article | 11 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02848-4

Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial Christine E. Brown, Jonathan C. Hibbard, Darya Alizadeh, M. Suzette Blanchard, Heini M. Natri et al. Article | 07 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02875-1

A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results Amy R. Rappaport, Chrisann Kyi, Monica Lane, Meghan G. Hart, Melissa L. Johnson et al. Article | 27 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02851-9

Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA analyses Ronan J. Kelly, Blair V. Landon, Ali H. Zaidi, Dipika Singh, Jenna V. Canzoniero et al. Article | 19 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02877-z

Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial Feng Wang, Ying Jin, Min Wang, Hui-Yan Luo, Wei-Jia Fang et al. Article | 04 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02813-1

Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial Mark Yarchoan, Edward J. Gane, Thomas U. Marron, Renzo Perales-Linares, Jian Yan et al. Article | 07 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02894-y

Risk-based lung cancer screening performance in a universal healthcare setting Martin C. Tammemägi, Gail E. Darling, Heidi Schmidt, Meghan J. Walker, Deanna Langer et al. Article | 19 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02904-z

Multi-ancestry polygenic mechanisms of type 2 diabetes Kirk Smith, Aaron J. Deutsch, Carolyn McGrail, Hyunkyung Kim, Sarah Hsu et al. Article | 05 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02865-3

A multi-ancestry genetic study of pain intensity in 598,339 veterans Sylvanus Toikumo, Rachel Vickers-Smith, Zeal Jinwala, Heng Xu, Divya Saini et al. Article | 01 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02839-5

Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests Nicolas R. Barthélemy, Gemma Salvadó, Suzanne E. Schindler, Yingxin He, Shorena Janelidze et al. Article | 21 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02869-z

Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease Gennaro Pagano, Kirsten I. Taylor, Judith Anzures Cabrera, Tanya Simuni, Kenneth Marek et al. Article | 15 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02886-y

Enhanced cholera surveillance to improve vaccination campaign efficiency Hanmeng Xu, Kaiyue Zou, Juan Dent, Kirsten E. Wiens, Espoir Bwenge Malembaka et al. Article | 05 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02852-8

Implementation of pooled saliva tests for universal screening of cCMV infection Lior Merav, Noa Ofek Shlomai, Esther Oiknine-Djian, Orit Caplan, Ayala Livneh et al. Article | 08 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02873-3

Impact of extreme weather events on healthcare utilization and mortality in the United States Renee N. Salas, Laura G. Burke, Jessica Phelan, Gregory A. Wellenius, E. John Orav et al. Article | 29 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02833-x

Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial Marcia Scazufca, Carina Akemi Nakamura, Nadine Seward, Thiago Vinicius Nadaleto Didone, Felipe Azevedo Moretti et al. Article | 14 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02864-4

Adapted large language models can outperform medical experts in clinical text summarization Dave Van Veen, Cara Van Uden, Louis Blankemeier, Jean-Benoit Delbrouck, Asad Aali et al. Article | 27 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02855-5

Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing Nienke J. Mekkes, Minke Groot, Eric Hoekstra, Alyse de Boer, Ekaterina Dagkesamanskaia et al. Article | 12 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02843-9

Transparent medical image AI via an image–text foundation model grounded in medical literature Chanwoo Kim, Soham U. Gadgil, Alex J. DeGrave, Jesutofunmi A. Omiye, Zhuo Ran Cai et al. Article | 16 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02887-x

Generative models improve fairness of medical classifiers under distribution shifts Ira Ktena, Olivia Wiles, Isabela Albuquerque, Sylvestre-Alvise Rebuffi, Ryutaro Tanno et al. Article | 10 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02838-6

Demographic bias in misdiagnosis by computational pathology models Anurag Vaidya, Richard J. Chen, Drew F. K. Williamson, Andrew H. Song, Guillaume Jaume et al. Article | 19 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02885-z

Effectiveness and safety of telehealth medication abortion in the USA Ushma D. Upadhyay, Leah R. Koenig, Karen Meckstroth, Jennifer Ko, Ena Suseth Valladares et al. Article | 15 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02834-w

Analysis

Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease Anubha Agarwal, Priya M. Mehta, Tyler Jacobson, Nilay S. Shah, Jiancheng Ye et al. Analysis | 26 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02896-w

Amendments & Corrections

Author Correction: Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results Andras Heczey, Xin Xu, Amy N. Courtney, Gengwen Tian, Gabriel A. Barragan et al. Author Correction | 09 January 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02799-w

Author Correction: The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells Di Zhu, Zhongqiu Wang, Jian-Jun Zhao, Teresa Calimeri, Jiang Meng et al. Author Correction | 25 January 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02820-2

Author Correction: Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial Matthew D. Galsky, Siamak Daneshmand, Sudeh Izadmehr, Edgar Gonzalez-Kozlova, Kevin G. Chan et al. Author Correction | 19 January 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02814-0

Author Correction: Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women Alessandro Cherubini, Mahnoosh Ostadreza, Oveis Jamialahmadi, Serena Pelusi, Eniada Rrapaj et al. Author Correction | 24 January 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02817-x

Author Correction: Health effects associated with exposure to secondhand smoke: a Burden of Proof study Luisa S. Flor, Jason A. Anderson, Noah Ahmad, Aleksandr Aravkin, Sinclair Carr et al. Author Correction | 30 January 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02832-y

Author Correction: The IDEAL framework for surgical robotics: development, comparative evaluation and long-term monitoring Hani J. Marcus, Pedro T. Ramirez, Danyal Z. Khan, Hugo Layard Horsfall, John G. Hanrahan et al. Author Correction | 31 January 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02836-8

Author Correction: Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity Douglas. W McMillin, Jake Delmore, Ellen Weisberg, Joseph. M Negri, Corey. D Geer et al. Author Correction | 14 February 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02847-5

Retraction Note: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Dong Liu, Tong Cheng, Huang Guo, José A. Fernández, John H. Griffin et al. Retraction | 20 March 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02916-9

Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Axel Montagne, Angeliki M. Nikolakopoulou, Zhen Zhao, Abhay P. Sagare, Gabriel Si et al. Retraction | 05 April 2024 Nature Medicine 30 | doi:10.1038/s41591-024-02935-6

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