Dear gustavo.braslavsky.clinical,
We are looking for employees working remotely.
My name is Toby, I am the personnel manager of a large International company.
Most of the work you can do from home, that is, at a distance.
Salary is $2300-$5900.
If you are interested in this offer, please visit Our Site
d_health Good day!
Re: Salary [$1000 /week]
‘Worst imaginable’ childhood brain tumours treated by CAR-T cells
| |||||
| |||||
| Hello Nature readers, | |||||
 | |||||
| The childhood brain cancer known as diffuse intrinsic pontine glioma (DIPG) is usually a death sentence, but engineered immune cells might help to shrink tumours. (Credit: Living Art Enterprises/Science Photo Library) | |||||
CAR T shrinks 'worst imaginable' tumourEngineered chimeric antigen receptor (CAR) T cells can shrink a rare childhood brain tumour known as diffuse intrinsic pontine glioma (DIPG). Researchers designed CAR-T cells to target a molecule called GD2 that sits on the surface of DIPG tumour cells. The therapy shrunk four out of eleven children's tumours by at least 50%, and one person has remained in remission for 30 months. Nine of the eleven people ultimately died, but researchers say the therapy is a positive development in treating what has been called the "the worst imaginable childhood brain tumour" because of its nearly 100% fatality rate. STAT | 6 min read (paywall)Reference: Nature paper | |||||
Stem-cell transplants restore lost visionThree people with severely impaired vision can see significantly better thanks to a stem-cell transplant. These improvements have now lasted more than a year. A fourth person also experienced a boost in their vision, but it did not last. The four are the first to receive a transplant of reprogrammed stem cells to treat damaged corneas, the transparent outer surface of the eye. The team behind the treatment will launch larger clinical trials next year. Nature | 4 min readReference: The Lancet paper | |||||
South Africa floats heritable gene editingSouth Africa has amended its health-research ethics guidelines to include a new section on heritable (or germline) human genome editing. The move could put the nation one step closer to being the first to explicitly allow the controversial technique, which involves making genetic changes to sperm, eggs or embryos that could be passed down to future generations. Such editing could prevent inherited diseases, such as cystic fibrosis and sickle-cell disease, but it poses major ethical concerns and safety challenges. Nature | 5 min read | |||||
| |||||
 | |||||
| Researchers made these tomatoes (Solanum lycopersicum) extra sweet by using CRISPR-Cas9 to deactivate two genes that degrade sugar-production enzymes. The modification didn't affect the fruits' size — like other modern cultivated tomatoes, they are up to 100 times larger than their wild counterparts. (Nature | 4 min read) Reference: Nature paper (Credit: Zhang, J., Lyu, H., Chen, J. et al., Nature) | |||||
| |||||
How weight-loss drugs will change the world"Short of some crazy unfortunate side effect, this is going to change the world," says gastroenterologist Chin Hur about blockbuster GLP-1 agonist drugs such as semaglutide, which is sold as Ozempic for diabetes and Wegovy for weight loss. Reducing obesity globally could have huge societal advantages, from improving people's quality of life to reducing health and education disparities, but their future benefit is still shrouded in uncertainty. The long-term health impacts of these drugs are unclear, and they remain prohibitively expensive for most people, leaving medical researchers and companies scrambling to gather more data and develop better tools to assess how weight-loss drugs could transform societies. Nature | 11 min read | |||||
Can amyloid therapies treat many diseases?Amyloid, the sticky protein best known for its role in Alzheimer's disease, is involved in many other disorders including amyotrophic lateral sclerosis (ALS) and certain types of heart disease. Researchers have identified 39 'amyloidogenic' proteins that can misfold and accumulate in organs throughout the body. Several therapies — including antibodies, genetic editing systems and small-molecule drugs — are now in late-stage clinical trials for treating the 'systemic amyloidoses' that occur when a misfolded protein creates fibrils that damage an organ. One company is even developing a 'pan-amyloid' drug that targets any protein with a specific molecular structure. Nature Biotechnology | 10 min read | |||||
Cadavers could be bone-marrow donorsA new technique for collecting bone-marrow stem cells from a cadaver's spinal column could provide transplants for people with blood cancers. A company called Ossium Health is creating a bank of cryopreserved marrow from organ donors with diverse genetic backgrounds. Unlike solid organ donors, a bone-marrow donor must be a very close genetic match to the recipient. This presents a particular challenge when trying to find donors for people from racial minority groups, who are underrepresented in donor registries. The cadaver bank could widen the potential donor pool, although it is still unclear whether the freezing process could damage the stem cells. Wired | 8 min read | |||||
| |||||
| |||||
Quote of the week"Cats, lemurs, mice are all useful. We shouldn't focus all our efforts on one."Comparative neuroscientist Christine Charvet argues that non-traditional model organisms offer unique insights into human conditions such as ageing. A study known as Translating Time is collecting health records, blood tests and brain scans from cats to map events along the nonlinear relationship between cat and human ages. (Nature | 5 min read) | |||||
| | |||||
| |||||
| | |||||
Free newsletters from NatureWant more? Update your preferences to sign up to our other Nature Briefing newsletters:
| |||||
Access Nature and 54 other Nature journals Nature+ is our most affordable 30-day subscription, giving you online access to a wide range of specialist Nature Portfolio journals, including Nature. | |||||
| |||||
| You received this newsletter because you subscribed with the email address: gustavo.braslavsky@gmail.com Please add trbriefing@nature.com to your address book. Enjoying this newsletter? You can use this form to recommend it to a friend or colleague — thank you! Had enough? To unsubscribe from this Briefing, but keep receiving your other Nature Briefing newsletters, please update your subscription preferences. To stop all Nature Briefing emails forever, click here to remove your personal data from our system. Fancy a bit of a read? View our privacy policy. Forwarded by a friend? Get the Briefing straight to your inbox: subscribe for free. Get more from Nature: Register for free on nature.com to sign up for other newsletters specific to your field and email alerts from Nature Portfolio journals. Nature Portfolio | The Springer Nature Campus, 4 Crinan Street, London, N1 9XW, United Kingdom Nature Portfolio, part of Springer Nature. |
Act. Laboral, Procedimientos de término de contrato, dos tardes
|
REPARACIONES INSTALACIONES DE RIEGOS AUTOMATICOS INTELIGENTES
|
I would like to ask you
|
IFSO-EC VENICE 2025 - EARLY BIRD REGISTRATION AND ABSTRACT SUBMISSION ARE OPEN!
|
.png)
 | ||||
| ||||
| ||||
‘My paper got a huge readership’: the fun of winning science’s satirical Ig Nobel prize
| |||||
| |||||
| Hello Nature readers, | |||||
 | |||||
| Chang'e-6 was China's second mission to land on the lunar far side, after Chang'e-4 in 2019. Both landed in the South Pole-Aitken Basin, one of the Moon's oldest and largest craters. (Xinhua/Shutterstock) | |||||
First analysis of rocks from Moon's far sideTwo groups of researchers have taken the first-ever look at samples brought back from the Moon's far side — and revealed a history of volcanic activity that spans billions of years. Nearly two kilograms of lunar soil was retrieved by the China National Space Administration mission Chang'e-6 and then dropped down to Earth in a re-entry capsule. Scientists found grains of dust in the sample that originated from lava that erupted to the surface as long as 4.2 billion years ago. Nature | 5 min readReference: Nature paper & Science paper | |||||
Fat cells can 'remember' obesityThe body's fat cells carry a 'memory' of obesity, even after weight loss. The memory is formed because obesity causes epigenetic changes in the cells, which seem to render them incapable of their normal function even when weight returns to healthy levels. The results suggest that people trying to slim down will often require long-term care to avoid weight regain, says biologist and study co-author Laura Hinte. "It means that you need more help, potentially," she says. "It's not your fault." Nature | 5 min readReference: Nature paper | |||||
Google Scholar faces AI competitorsGoogle Scholar is turning 20 — and facing the rise of competing systems, powered by artificial intelligence (AI), for searching the literature. "If there was ever a moment when Google Scholar could be overthrown as the main search engine, it might be now," says computational social scientist Jevin West. Anurag Acharya, who co-founded Google Scholar, says he welcomes all efforts to make scholarly information easier to find, understand and build on. Nature | 6 min read | |||||
| |||||
The 'silly' science prize changing careersUnlike its Nobel namesake, an Ig Nobel prize is not always coveted by scientists. But receiving one of the the satirical awards — which honour work that "makes people laugh, then think" — is no bad thing, say some former winners. "My paper got a huge readership," says ornithologist Kees Moeliker, who won in 2003 for reporting the first documented case of homosexual necrophilia in ducks. Psychologist Minna Lyons, who won in 2014 for her work on the dark personality traits of night-owls, calls the award "one of the best surprises in my academic career, by far". "It actually inspires people," she says. Nature | 9 min readReference: DEINSEA paper & Personality and Individual Differences paper | |||||
'Science, at its most basic, is apolitical'"The scientific community must take a critical look at what responsibility it bears in science becoming politically contentious," argues Marcia McNutt, the president of the US National Academy of Sciences. She emphasizes the role of evidence in informing — not setting — policy. And she says that "it may not be helpful to emphasize consensus in policy reports' recommendations when the underlying values are not universally shared" — for example, by being prescriptive about the use of renewable energy to address climate change. In 2020, Nature explored why we write (and podcast) about politics in a three-part audio series that considers the intimate relationship between politics and science. | |||||
The return of a vanished Hawaiian islandIn 2018, Hurricane Walaka wiped a tiny island in the remote northwest of the Hawaiian archipelago off the map. With it went a refuge for threatened green sea turtles (Chelonia mydas) and critically endangered Hawaiian monk seals (Neomonachus schauinslandi). But East Island is making a comeback: it has regained about 60% of its original size, along with some turtle nesting sites and seals. "It was a tragic event but there's just so much knowledge that we're gaining," says climate scientist Haunani Kane. This "will help to guide our long-term understanding of how our islands are resilient or vulnerable to the changes that are to come". Honolulu Civil Beat | 16 min read | |||||
Quote of the day"Is it feasible? The answer is absolutely yes. Is it politically challenging? The answer is also yes."Amar Bhattacharya, executive secretary of the UN's independent high-level expert group on climate finance, recognizes that wrangling US$1 trillion a year by 2030 to meet the goals of the Paris Agreement is no mean feat. But without it, the world risks a future of climate-change-driven economic turmoil. (The Guardian | 5 min read) | |||||
| | |||||
| |||||
| | |||||
Free newsletters from NatureWant more? Update your preferences to sign up to our other Nature Briefing newsletters:
| |||||
Access Nature and 54 other Nature journals Nature+ is our most affordable 30-day subscription, giving you online access to a wide range of specialist Nature Portfolio journals, including Nature. | |||||
| |||||
| You received this newsletter because you subscribed with the email address: gustavo.braslavsky@gmail.com Please add briefing@nature.com to your address book. Enjoying this newsletter? You can use this form to recommend it to a friend or colleague — thank you! Had enough? To unsubscribe from this Briefing, but keep receiving your other Nature Briefing newsletters, please update your subscription preferences. To stop all Nature Briefing emails forever, click here to remove your personal data from our system. Fancy a bit of a read? View our privacy policy. Forwarded by a friend? Get the Briefing straight to your inbox: subscribe for free. Want to master time management, protect your mental health and brush up on your skills? Sign up for our free short e-mail series for working scientists, Back to the lab. Get more from Nature: Register for free on nature.com to sign up for other newsletters specific to your field and email alerts from Nature Portfolio journals. Would you like to read the Briefing in other languages? 关注Nature Portfolio官方微信订阅号，每周二为您推送Nature Briefing精选中文内容——自然每周简报。 Nature Portfolio | The Springer Nature Campus, 4 Crinan Street, London, N1 9XW, United Kingdom Nature Portfolio, part of Springer Nature. |
Subscribe to:
Posts (Atom)